Search on: RIBOSOME INACTIVATING PROTEINS 
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Descriptor English:   Ribosome Inactivating Proteins 
Descriptor Spanish:   Proteínas Inactivantes de Ribosomas 
Descriptor Portuguese:   Proteínas Inativadoras de Ribossomos 
Synonyms English:   RNA N-Glycosidase  
Tree Number:   D08.811.277.450.430.700
D12.776.765.710
Definition English:   N-Glycosidases that remove adenines from RIBOSOMAL RNA, depurinating the conserved alpha-sarcin loop of 28S RIBOSOMAL RNA. They often consist of a toxic A subunit and a binding lectin B subunit. They may be considered as PROTEIN SYNTHESIS INHIBITORS. They are found in many PLANTS and have cytotoxic and antiviral activity. 
Pharmacological Action:   Protein Synthesis Inhibitors
 
History Note English:   2008(1988) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   52713 
Unique Identifier:   D054788 

Occurrence in VHL:
 

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